Gastown is still establishing itself as a gastronomical center - between Salt, McLean's Deli (fronted by VANCOUVER HERO CAPTAIN KIRK MCLEAN), Chill Winston, Meat & Bread and Alibi Room, there's a great base there to choose from.
Irish Heather moved to new digs which I'm not so chuffed about. I preferred the old, cramped place with the seat and tables in the back looking out towards the alley. Watching human misery while drinking beer is a unique experience.
Chambar is more of an outskirts-of-Gastown place, but oh my goodness is the food amazing (and bloody expensive). I saw my first and only Black Amex at Chambar - I will cherish that memory forever.
Main Street between 7th and 33rd is seeing a lot more restaurant activity. You have already established place like East is East (best Afghan food on the planet outside of Afghanistan), Crave, the rebuilt Lickety Split, Splitz Grill for burgers. Even the also rans like Burgoo are pretty good.
The world's greatest noodle place is also tucked away on Main Street - Legendary Noodle. Go there before you die.